Rheumatoid Arthritis: It's the food!

I had an email query about Rheumatoid Arthritis, so off to PubMed I went.

From http://www.webmd.com/rheumatoid-arthritis/ss/slideshow-ra-overview

I found Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis.

"Fasting is an effective treatment for rheumatoid arthritis, but most patients relapse on reintroduction of food."
This suggests that rheumatoid arthritis (RA) is an ongoing process, triggered by something that's consumed.

"After an initial 7-10 day subtotal fast, they were put on an individually adjusted gluten-free vegan diet for 3.5 months. The food was then gradually changed to a lactovegetarian diet for the remainder of the study."
Are you thinking what I'm thinking? I'm thinking Gliadorphin-7, as per Wheat, Constipation, Ischaemic Heart Disease, Type 1 Diabetes, Schizophrenia and Autism.

This suggests that RA is caused by peptide chains passing through loose "tight junctions" in the gut, triggering an (inappropriate) autoimmune response. For ways to improve gut integrity, see Cow's milk, Schizophrenia and Autism.

BCM-7 can be avoided by drinking A2 milk. Most cheeses are made from A1 milk, so should be avoided. Swiss cheeses like Gruyère and Emmental are probably made from A2 milk, so suck 'em and see.

To reduce inflammation in joints, consuming oily fish may help, as an adjunct to prescribed anti-inflammatory medications.

Historical perspectives on the impact of n-3 and n-6 nutrients on health, by Bill Lands.

Here's Fig. 1. from http://www.sciencedirect.com/science/article/pii/S0163782714000253

Relating tissue HUFA balance with blood cholesterol and heart attacks. Results from the 25-year follow-up in the Seven Countries Study [35] were discussed in an earlier review [10] which noted that “Food energy imbalances which elevate blood cholesterol may be fatal only to the degree that omega-6 (n-6) exceeds omega-3 (n-3) in tissue HUFA. Such evidence raises questions about the hypothesis that blood cholesterol levels cause CHD.” Northern Europe and Southern Europe have abbreviations “No.” and “So.”, respectively. The Figure is reprinted with permission of the publisher.

Hat-tip to Dr. Thomas Dayspring for Tweeting this review.

Fig. 1 is interesting, as it shows a significant association between 25-year CHD mortality and Serum Total Cholesterol for every region except Japan. What's different about Japan, compared to Northern Europe, USA, Serbia, Southern Europe & Crete?

According to Measuring Blood Fatty Acids as a Surrogate Indicator for Coronary Heart Disease Risk in Population Studies , Philippines & Iceland have lower % linoleic acid than Japan. Where's the CHD vs TC data?

Could another difference be that the Japanese eat rice, a relatively intact grain, instead of foods made from wheat grain dust (i.e. flour) as their main source of dietary carbohydrates?

See also Using 3–6 differences in essential fatty acids rather than 3/6 ratios gives useful food balance scores , and Omega 3-6 Balance Score.

How many working brain cells do researchers have? Part n+1

Once upon a time, I took the mickey out of some eejit researchers in How many working brain cells do researchers have? Guess what? I'm doing it again. A Facebook friend sent me a link to a worrying "new" study Omega-3 Supplements Linked To Prostate Cancer. Oh, dear. Things are looking bad for oily fish & fish oil supplements. Just a moment!

I did some digging on PubMed for the author and found this:- n-3 Fatty acids and prostate cancer risk. The main feature of wild oily fish & fish oil supplements is their high ratio of EPA & DHA (long-chain omega-3 fatty acids) to LA (a shorter-chain omega-6 fatty acid). It would therefore be logical to assess oily fish consumption and/or fish oil supplement intake by measuring the ratio of serum EPA:LA and/or DHA:LA and/or (EPA+DHA):LA.

What did Brasky TM, Crowe FL & Kristal AR actually do? According to the abstract, they measured only serum EPA, DHA & (EPA+DHA). They didn't measure serum LA. Therefore, if the subjects in the EPIC study ate a diet with a high omega-6 (n-6):omega-3 (n-3) ratio (i.e a Standard English Diet), subjects with a high serum n-3 level would have a very high serum n-6 level. As excessive levels of serum n-6 pufas are carcinogenic (see Completing the trine: Which are the safest fats?), it's not surprising that the study produced the results that it did.

There only one thing to do, in cases like this...

Because one palm just isn't enough!

EDIT: Here's a better analysis:- Fish Oil and your Prostate. It looks as though n-6 was measured, which makes my analysis wrong, but I'm keeping the double face-palm, as the full study is hidden behind a £30 pay-wall. Here's another good analysis:- Omega-3 Fats and Cancer.

Completing the trine: Which are the safest fats?

First, watch this video by Chris Masterjohn.

Diets very high in pufas (polyunsaturates) are not beneficial to heart health or longevity. Flora? No thanks!

Here's a chart. The beige & grey bars represent pufas (omega-6 & omega-3).

Comparison of dietary fats

The yellow bars represent monounsaturates and the orangey-red bars represent saturates. I consider these to be harmless, as long as you don't go mad and eat them in such large amounts that you gain weight.

Bearing in mind the information in the video, plus the information in Fats: Spawn of Satan or Dogs' Doodads? , I use only fats from the bottom 6 for cooking (olive oil and butter, actually).

Flaxseed oil can be used as an omega-3 supplement for vegetarian/vegan women, as omega-3 pufas are as rare as rocking-horse poo in most foods (apart from oily fish).

Non-vegetarian/vegan people can get their long-chain omega-3 pufas (EPA & DHA) from oily fish. As vegetarian/vegan men barely produce any DHA from the omega-3 in flaxseed oil, they should get it from algal DHA supplements. See Extremely Limited Synthesis of Long Chain Polyunsaturates in Adults: Implications for their Dietary Essentiality and use as Supplements.

Cancer, part 2.

In cancer, I discussed omega-3 and methylglyoxal.

Methylglyoxal

This time, I'm just going to do a Research Review, by publishing a list of PubMed searches with the following Filters activated: Abstract available, published in the last 10 years, Humans.

Cancer AND "Dichloroacetic Acid".

Cancer AND "Magnesium".

Cancer AND "Methylglyoxal".

Cancer AND "Omega-3".

Cancer AND "Vitamin D3".

Cancer AND "Vitamin K2".

I added searches for Magnesium and Vitamin K2, as I supplement with those and want to see if they have a positive or negative effect on Cancer. I added Dichloroacetic Acid (DCA), as I've read about it.

PPP - another bijou rant-ette.

Blame it on the hot weather and screaming kids! :-D

PPP stands for Piss Poor Parenting.

Why, oh why, oh why do parents allow children to dictate their own diets? As if children know what's good for them! At an event I attended recently, "Johnny*" was given a plate of chicken drummers (mechanically-recovered chicken formed into the approximate shape of chicken drumsticks and coated with breadcrumbs) and oven chips. I asked Johnny if he would like a beefburger, sausage or pork steak. He replied. "I don't like them". He only wanted manufactured shite. Seriously, WTF?

When I was a lad, I was given the same food as my parents. If I didn't eat it, I went without. I ate it!
Nowadays, "children's menus" in restaurants (I'm being quite generous in the use of the word restaurant) consist of lots of manufactured shite that children like. Unlike veggies & fruit, this shite contains very little fibre/fiber or magnesium.

Is it any wonder that childhood constipation is a problem? Why are children being given PEG or even Lactulose, when there's a much better solution - Epsom Salts (which contains magnesium). The gut needs magnesium to function properly. See You're free, and a testimonial.

The brain needs magnesium to remain cool, calm and collected i.e. function properly. The brain also needs DHA and Vitamin D3 to function properly. Many kids don't like oily fish so they won't/don't eat it. It's not rocket science to purée some wild red salmon with some Bolognese/Sweet chilli/w.h.y. sauce so that they won't notice it. Many kids play indoors or are smothered in sunblock when they do go outdoors. Is it any wonder that childhood ADD/ADHD is much more common? Medication and psychotherapy? Seriously, WTF?

When I was a lad, there were a couple of show-offs in my class at school, but nobody behaved like "Jimmy*" (physically and mentally hyperactive with bad behaviour, screaming and shouting). Johnny was also badly behaved, but not as bad as Jimmy. The parents at the event seemed content that, every day, their children had to be given "uppers" (e.g. Ritalin) to help them concentrate during the day and "downers" to help them sleep at night. Seriously, WTF?

I will now take a deep breath and count to twenty. There, that's better!

*Names changed.

Move More: You are NOT going to believe this! Part 2.

At mum's care home on Wednesday, the activities ladies held a tai-chi session for the residents, as movement is good for their muscles and well-being. They roped me in as well. Mum was reading a Henley-on-Thames leaflet so she didn't join-in.

Tai-chi is harder than it looks! Mum noticed that I was waving my arms about in a graceful manner and stopped reading the leaflet. She looked slightly bemused (as would you if you saw what I was doing) and started smiling.

It was also somebody's birthday, so we all sang "Happy birthday to you" to him and gave him three "hip-hip hoorays" followed by a round of applause.

To the astonishment of the activities ladies, mum started to clap her hands. 5,000iu/day of Vitamin D3 + me being chatty, For The Win!

The nurse on duty also had a chat with me about the best way to give mum 10ml/day of fish oil and 2.5ml/day of Epsom Salts. She later told me that mum swallowed the fish oil without any problems (mum loves smoked salmon) and swallowed the Epsom Salts dissolved in a cup of juice without any problems either.

In other news, I now have a Blackberry 8900. This blog looks rather different when displayed on a tiny screen.

EDIT: I now ache all over!

Get in! Parts 2 & 3.

In Get in!, I described how I persuaded mum's GP to let mum have Vitamin D3 5,000iu/day.

Well...

Today, I persuaded mum's GP to let mum have Epsom Salts 2.5g/day (provided by me) dissolved in fruit juice and Seven Seas Fish Oil 10ml/day (provided by me). There's only one possible reaction:-


P.S. The doctor didn't even ask for supporting evidence. He just said "Yeah, other relatives do that. No problem. He just wanted to check for contraindications, which is fine by me. I have plans to ask him to allow mum to have one more supplement that may help her bones & brain. Any ideas as to what that might be, O.K.?

P.P.S. Another lady that's been at the care home since day one died Wednesday night/Thursday morning. She died from terminal cancer, but she had been physically crippled by Parkinson's Disease. R.I.P.

The usual suspects.

On Facebook, on message boards and in conversation, I often see and hear:-

1. I'm down in the Winter/I keep getting infections/I have allergies/I have aches & pains.

2. I'm up & down a lot.

3. I'm down/I'm anxious/I can't sleep/I get restless legs/cramps/menstrual cramps/muscle spasms/lung spasms/migraines.

4. I've got inflamed or painful joints/skin/guts/lungs/w.h.y.


1. Vitamin D insufficiency/deficiency is widespread by the end of Winter (~90% of people have serum 25(OH)D less than 75nmol/L or 30ng/mL) due to insufficient sun exposure (or sun exposure through glass) during the Summer. A safe & effective dose is 50iu of Vitamin D3 per kg weight per day. See Vitamin D.

2. Modern diets are lacking in long-chain omega-3 fatty acids (EPA & DHA), as many people don't eat any/enough oily fish. Tinned tuna is not an oily fish! See Omega-3 fatty acids and major depression: A primer for the mental health professional. Women of reproductive age can take flaxseed oil, if they can't/won't eat oily fish or take fish oil capsules. Women not of reproductive age & men need to supplement with vegan DHA in addition to flaxseed oil, if they can't/won't eat oily fish or take fish oil capsules.

3. Diets low in greens are low in magnesium. Excessive stress increases loss of magnesium in urine. Magnesium deficiency can cause all of the above symptoms. Epsom Salts are a very cheap source of Magnesium. 4g/day of Epsom Salts provides 400mg/day of Magnesium. See Magnesium and the Ketamine Connection , Magnesium and the Brain: The Original Chill Pill , and Magnesium: Just as important as Calcium.

4. Vitamin D and omega-3 fatty acids are anti-inflammatory.


Difficult-to-treat health problems such as depression are often multifactorial (with physiological AND psychological causes), so it's advisable to try 1. 2. and 3. (with your GP's consent). If you get improvement, you can discontinue supplements one at a time with a washout period of two months for 1. and 2. to see which supplement(s) was/were effective.

Here's a picture to go with the title.


And finally...
I'm so glad that I don't work with David Thorne.

Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet

Thanks to Stephan Guyenet for bringing the study n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials to my attention in his post Diet-Heart Controlled Trials: a New Literature Review. This shows that diets high in omega-6 (n-6) polyunsaturates but low in omega-3 (n-3) polyunsaturates are heart-unhealthy.

In the West, we are advised to eat lots of "heart-healthy" sunflower oil & spreads. These contain about 70 times more omega-6 than omega-3. Safflower, Grapeseed, Corn & Groundnut Oils also have high omega-6:omega-3 ratios, according to Comparison of Dietary Fats Chart.

I then found the following study also on the British Journal of Nutrition:- Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet.

This shows that traditional hunter-gatherer diets have a short-chain omega-3:omega-6 ratio of 1·12–1·64 and a long-chain omega-3:omega-6 ratio of 0·84–1·92. In other words, there is a moderate balance between omega-6 and omega-3 polyunsaturates.

The diets are also relatively high in protein (25–29% energy) and fat (30–39% energy) but moderate in carbohydrate (39–40% energy).

I thought that followers of a Paleo-type diet would find this interesting.

EDIT: I've just noticed that O Primitivo has already posted about this study!

Cancer.

By request, I'm writing about cancer. I didn't know this, but cancer is now the No.1 killer of men in the UK. I previously thought that coronary heart disease was the No.1 killer.

Cancer is such a huge subject that, rather than oversimplify it, I'll put a link to Wikipedia. Warning: Pictures of tumours.

Vitamins get a mention, particularly Vitamin D, but EFAs aren't mentioned. This is odd, as typing "Omega-3 Cancer" into PubMed yields 612 human studies going back to 1984. Here are some of them:-

Some effects of the essential fatty acids linoleic acid and alpha-linolenic acid and of their metabolites gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and of prostaglandins A1 and E1 on the proliferation of human osteogenic sarcoma cells in culture.

Selective killing of human cancer cells by polyunsaturated fatty acids.

Chronic arachidonic acid eicosanoid imbalance: a common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases. Significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway.

n-3 fatty acids and cancer.

Fish consumption and breast cancer risk: an ecological study.

Effect of docosahexaenoic acid on rate of differentiation of HL-60 human leukemia.

N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France.

Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health Study.

Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid.

Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer.

Nutritional knowledge of primary health care physicians in Jeddah, Saudi Arabia.

13.12.09: Some newer studies:-

A systemic review of the roles of n-3 fatty acids in health and disease.

Anticancer actions of omega-3 fatty acids--current state and future perspectives.

The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential.

Therapeutic potential of n-3 polyunsaturated fatty acids in disease.

Fish oil enhances the antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 on liver cancer cells.


EDIT: I've been reading about a substance called methylglyoxal, a glycolysis inhibitor. As many types of malignant cancer cells rely on the glycolysis pathway for energy, methylglyoxal looks like a promising anti-cancer agent.

See In vivo assessment of toxicity and pharmacokinetics of methylglyoxal. Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine,

A brief critical overview of the biological effects of methylglyoxal and further evaluation of a methylglyoxal-based anticancer formulation in treating cancer patients,

Selective inhibition of mitochondrial respiration and glycolysis in human leukaemic leucocytes by methylglyoxal and

Critical evaluation of toxic versus beneficial effects of methylglyoxal.

It looks like the Indians are ahead of everyone else on this stuff.
Well, well, well. Controversy!

"Methylglyoxal is a regular chemical, not cleared for human use. It is made without conforming to sound manufacturing practices and widely respected codes of good laboratory practices followed throughout the world." O, RLY? See below.

"The IACS' main supplier of Methylglyoxal is an American warehouse corporation, Sigma Medical Company, which sells it for research purposes at $1 to 2 per gramme and specifically states that none of its chemicals is meant for medical use." If everyone stuck to the "rules", humankind would never make any progress.

The principal scientist involved is Professor Manju Ray, a biochemist, not a pharmacologist or cancer specialist." Biochemists know how cells work, so I would say that's a plus point, not a minus point. It's also argumentum ad-hominem.

"The "secret" of the "miracle" lies in the anti-tumour effect of Methylglyoxal - a property shared by hundreds of toxic chemicals. Methylglyoxal, it is claimed, inhibits electron flows in cancerous cells and blocks a crucial step necessary for the production of ATP, the cellular energy "currency". Methylglyoxal isn't anywhere near as toxic as standard chemotherapy drugs. Someone needs to learn some basic biochemistry!

"A critical ingredient, a control group with which the treated patients are compared, is absent from the study." It's unethical to have one group denied a treatment that might save their lives. The Lyon Diet-Heart trial was discontinued because the control group had a much higher mortality than the treated group.

"The researchers treated 24 patients, mostly in highly advanced stages of cancer, with oral administration of Methylglyoxal, with Vitamin C, over eight to 10 weeks. They claim that after treatment, 11 were in "excellent physical condition" and five were in a condition that "can be considered stable". "The rest either opted out of treatment or died during the course of study." This is disturbing enough." You left out the creatine and 0 out of 24 would almost certainly have survived without treatment.

"The study does not show how, through what process, the "cure" occurs." That's not the purpose of the study.

"What is equally astonishing is that the drug should be used in clinical trials on human beings in the first place. Such trials are permissible only after the pharmaco-kinetics (the way and the speed with which the body will handle the drug) is properly understood, and trials on experimental animals have been carried out. In this case, the first criterion was not fulfilled. And there is no mention of animal trials." An animal trial had been done. See the 1st study above.

So, when & where did it all go wrong?

No, I'm not talking about Demand Five! I'm talking about us, modern man & woman. We have improved hygiene, clean water & food, modern medicine, antibiotics, antivirals etc. We should be enjoying good health and vitality into our nineties. We're not, though. Degenerative diseases like Type 2 Diabetes, Coronary Heart Disease, Cancer, Dementia, IBS etc are afflicting increasing numbers of people (including youngsters) and are even starting to reduce our longevity statistics. Why?

On one side of the fence are the anti-animal fat brigade who claim that animal fats are the cause of all our health problems and that we should all be eating more vegetable fats and reducing our cholesterol.

On the other side of the fence are the anti-carb brigade who claim that carbohydrates are the cause of all our health problems and that we should all be eating less carbohydrates and increasing our fat consumption.

I'm sure you can guess where I am. I have the splinters to prove it!

In 1911, hydrogenated vegetable oil (Crisco) entered the marketplace. So, in 1911, fat turned bad! See The rise and fall of Crisco.

Interestingly, rates of Coronary Heart Disease started to rise from 1920, 9 years later. Co-incidence?

Our genes may have not changed much in the last few hundred thousand years, but our lifestyles certainly have. We now live mostly sedentary lives (which makes our muscles less sensitive to insulin). We now live and work mostly indoors (which makes us deficient in Vitamin D).

We now don't eat much oily fish. Our vegetables contain much less omega-3 fat than they used to (to make them stay fresh for longer). Our meat now contains much more omega-6 and much less omega-3 fat than it used to (due to feeding animals on grains). These changes make us deficient in omega-3 fat (which makes our muscles less sensitive to insulin).

We now eat loads of refined carbohydrate (which causes unstable blood glucose & insulin levels) and loads of processed foods (which makes us deficient in Magnesium and fibre/fiber).

As a result of all of the above changes, we have many modern diseases. We can't blame it on one factor only. So, what can we do? Here's one suggestion....



























Good health!

The Protein-Sparing Modified Fast (PSMF)

What's a PSMF?

A standard PSMF is ~1g of protein for every kg bodyweight per day plus lots of green leafy vegetables plus six to ten fish oil capsules per day plus vitamin & mineral supplements plus unlimited water AND NOTHING ELSE. It's a low-carbohydrate and low-fat diet. You may find this quite literally hard to swallow! PSMF may also stand for Protein Strictly , Mother-F***er!

A 100kg person (e.g. me) may get to eat ~400kcals per day from protein + ~100kcals per day from incidental carbohydrates & fats = ~500kcals per day. Hear that rumbling noise? It's my tummy! A well-known PSMF is Lyle McDonald's Rapid Fat Loss Handbook.

For more information, see http://forums.lylemcdonald.com/forumdisplay.php?f=7 and Is Rapid Fat Loss Right For You?

To make a PSMF easier to manage (but have a slower rate of weight loss), here are some modifications:-

1) Instead of six to ten fish oil capsules a day, stir ~25g of powdered linseeds into a large glass of drink and swallow the lot. Do this at breakfast-time. ~25g of linseeds contains ~10g of fat (of which ~6g is Alpha-Linolenic Acid, an omega-3 fatty acid) which does the following:-

a) It stimulates the gall-bladder to empty, thus reducing the risk of gallstones.
b) a) usually results in a bowel movement some time later. The ~10g of soluble fibre/fiber in the linseeds + accompanying fluid guarantees regularity.
c) It provides women (but not men) with all of the omega-3 fat they need each day.

Men need to eat either half a 213g tin of wild red salmon per day, or take six to ten fish oil capsules a day, as their bodies don't produce enough DHA from Alpha-Linolenic Acid. See Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men and  Extremely Limited Synthesis of Long Chain Polyunsaturates in Adults: Implications for their Dietary Essentiality and use as Supplements

2) Eat about 100g of protein per day. As meat, poultry & fish contains 20-25% protein, this means that you can eat ~1lb of meat, poultry & fish a day. 100g of protein per day is well within the capabilities of your liver and kidneys.

3) Eat about 44g of fat per day. This allows you to choose less lean cuts of meat & poultry and you can even eat the skin on chicken as long as you factor it into your total fat allowance. It also allows you to use vinaigrette salad dressings or a small knob of butter or a small dollop of real mayonnaise to make your vegetables taste nicer.

4) Eat about 50g of carbohydrate per day. This allows you to eat shed-loads of leafy green vegetables and also an onion. It also allows you to eat a portion of fruit e.g. an apple or a bowl of berries/cherries with Splenda & a small dollop of whipped cream each day.

5) If you do any intense exercise (e.g. HIIT or resistance training with weights), eat an extra 50g of slow-release carbohydrates a couple of hours beforehand, to fuel it.

6) Supplement with 5,000iu/day of Vitamin D3. Nowadays, many of us spend our lives mostly indoors, and this causes many of us to become deficient in Vitamin D. See Vitamin D.

7) Don't get too far away from a toilet. Rapid depletion of muscle & liver glycogen results in rapid shedding of associated water. In addition, the oxidation of fatty acids results in the production of water. A PSMF will make you pee more.

n*CH2 + 3/2*n*O2 = n*CO2 + n*H2O + heat

Saturated fatty acids are CH3-n*CH2-COOH. For Stearic acid, n=16. ∴ Stearic acid is mostly n*CH2. 



In conclusion:

100g of protein provides 400kcals, 44g of fat provides 400kcals and 50g of carbohydrate provides 200kcals, making a grand total of 1,000kcals per day. Hopefully, this will be enough to stop your tummy from rumbling. If you weigh over 100lbs but aren't losing weight on 1,000kcals per day, see your GP as you may have a thyroid problem.

I believe that the above diet tackles the problems of gallstones, constipation, dry skin, dry hair, depression and dietary deficiencies. You get to eat real food and quite a lot of it too, for a fairly rapid fat loss diet.

I've got a lovely bunch of coconuts!

Coconut Oil is the No. 1 most stable oil for cooking at high temperatures.

What’s in coconut oil?

According to McCance and Widdowson's “The Composition of Foods”, the fatty acid composition of coconut oil is as follows:-
Name(:0=sat, :1=mono, :2=poly, n6=omega-6) Quantity (%)
Caprylic Acid (C8:0)___________________________7.5
Capric Acid (C10:0)____________________________7.1
Lauric Acid (C12:0)___________________________47.7
Myristic Acid (C14:0)_________________________15.8
Palmitic Acid (C16:0)__________________________9.0
Stearic Acid (C18:0)___________________________2.4
Arachidic Acid (C20:0)_________________________1.0
Palmitoleic Acid (C16:1)_______________________0.4
Oleic Acid (C18:1)_____________________________6.6
Linoleic Acid (C18:2 n6)_______________________1.8

Won’t all that saturated fat give me a heart attack?

Whether or not you get coronary heart disease depends on your whole diet. According to http://www.ajcn.org/cgi/reprint/34/8/1552.pdf , Pukapukans got 26% (male) to 30% (female) of their total Calories from saturated fats. Tokelauans got 47% (male) to 49% (female) of their total Calories from saturated fats. Tokelauans had total serum cholesterol 35-40mg/dL (0.9- 1.03mmol/L) higher than Pukapukans.

As Tokelauans were getting about seven times more energy from saturated fats than the 7% that current healthy eating guidelines recommend, they must have been dropping like flies from coronary heart disease or strokes, right? Wrong! To quote:-

“Vascular disease is uncommon is both populations and there is no evidence of the high saturated fat intake having a harmful effect in these populations.” 

How come? Well, if you look at the rest of the Tokelauans’ diet, you’ll see virtually no refined sugar or cereal products. Basically, they weren’t eating any junk. When Tokelauans migrated to New Zealand, their sat fat intake fell to ~41% of total calories, but as they were eating more refined carbs & sugar, their lipid profile got worse.

What are the benefits of coconut oil?

Medium-chain fatty acids are metabolised rapidly without passing through the liver and they provide a quick source of energy for muscles. There is some evidence that medium-chain fatty acids stimulate the thyroid gland to secrete more T4 & T3 which can be an aid when cutting. There is also some evidence that Lauric Acid has anti-bacterial & anti-viral properties. Coconut oil is also good for the skin when rubbed in.

Where can I buy coconut oil?

Don’t buy cheap coconut oil. It’s almost certainly Refined, Bleached & Deodorised, which detracts from its health benefits. The best coconut oils are Organic Virgin Oils. Some good on-line sources are:-

http://www.fresh-coconut.com/ , Coconut Oil UK and https://www.revital.co.uk/search?q=Coconut+Oil

As sure as Eggs is Eggs.....

...is grammatically incorrect! Rumour has it that it's a corruption of "As sure as x = x". But anyway....

Eggs are very nutritious and should be eaten freely as part of a healthy diet.

Click http://www.nutritiondata.com/facts/dairy-and-egg-products/111/2 and set the serving size to 1 large (50g) to see what nutrients there are in a raw whole egg.

Click http://www.nutritiondata.com/facts/dairy-and-egg-products/112/2 and set the serving size to 1 large (33g) to see what nutrients there are in a raw egg white.

Click http://www.nutritiondata.com/facts/dairy-and-egg-products/113/2 and set serving size to 1 large (17g) to see what nutrients there are in a raw egg yolk.

The amino acid scores for whole egg , white and yolk are 136, 145 and 146 respectively. Eggs are a good source of complete proteins. This is because the yolk and white need to contain everything necessary for a growing chick embryo.


Can I drink eggs raw to save time?There are three potential problems with this:

1) Salmonella poisoning. Unless you’re pretty sure of the hens that the eggs came from, there is a risk of poisoning from raw eggs. This doesn’t apply to pasteurised eggs from suppliers like http://www.eggnation.co.uk/ for example.

2) Poor absorption of egg white protein. According to http://jn.nutrition.org/cgi/content/full/128/10/1716 , only 51% of raw egg white protein is absorbed during digestion compared to 91% for cooked egg white protein. According to http://ajpgi.physiology.org/cgi/content/full/277/5/G935 , the figures are 65% and 94% respectively. The second study used 200g of white and one yolk. I don’t believe that there is a problem with the absorption of raw egg yolk, though problem 1 still remains. Pasteurised egg white protein is well absorbed.

3) Poor biotin absorption. Raw egg white contains a glycoprotein called avidin which binds to biotin (Vit. B7) in the yolk and prevents its absorption. Cooking or pasteurisation denatures (changes the 3-D structure of) the avidin and renders it harmless.


What about all that cholesterol in egg yolks?

Current “Healthy Eating” guidelines state that we should eat no more than 3 egg yolks/whole eggs per week. This is based on the erroneous assumption that dietary cholesterol always increases serum cholesterol and that this is always a bad thing. According to http://www.ajcn.org/cgi/reprint/32/5/1051.pdf , adding or not adding 500mg of dietary cholesterol from two large eggs per day made no significant difference to serum cholesterol or triglycerides in 116 healthy male subjects. Some went up and some went down. Eddie Vos at http://www.health-heart.org/cholesterol.htm reckons that you’d have to eat 20 whole eggs per day to get as much dietary cholesterol as the liver produces each day (5g). Egg yolks do contain some fat and this should be factored into your total diet. If you happen to have the genes for familial hypercholesterolaemia, then you need to keep a close eye on dietary cholesterol intake. See also Eat Whole Eggs All Day and Throw Your Statins Away? 375x Increased Dietary Cholesterol Intake From Eggs Reduces Visceral Fat & Promotes Healthy Cholesterol Metabolism.

There is a problem with modern eggs though, and it’s caused by the food that’s fed to the hens. Grains contain about 50 times more Linoleic acid (omega-6) than Alpha-Linolenic acid (omega-3) and this raises the omega-6:omega-3 ratio of the eggs that the hens lay. Hens eating a natural diet of bugs, grubs and vegetation lay eggs with a 1:1 ratio of omega-6:omega-3, but grain-fed hens lay eggs with an omega-6:omega-3 ratio of >10:1. A high omega-6:omega-3 ratio in the diet is associated with increased risk factors for heart disease, cancer and Insulin Resistance (pre-type 2 diabetes). Therefore, if large numbers of cheapo eggs are eaten, it’s advisable to eat other foods that are rich in omega-3 fats.

Linseed/Flaxseed & Flaxseed oil.

"Where flax is eaten...health abounds!" - Mahatma Gandhi.

These little seeds pack a quadruple-whammy of protein, omega-3 Essential Fatty Acids (EFAs), soluble fibre/fiber and vitamins, minerals & other anutrients.


What's in flaxseed and flaxseed oil?

Click http://www.nutritiondata.com/facts/nut-and-seed-products/3163/2 and set serving size: to 100g, to see what nutrients there are in flaxseeds.
Click http://www.nutritiondata.com/facts/fats-and-oils/7554/2 and set serving size: to 100g, to see what nutrients there are in flaxseed oil.


How do I eat flaxseed and flaxseed oil?

Flaxseed/Linseed have a fibrous coat which swells-up when wet and passes through our guts undigested. To get the benefit of the protein, omega-3 essential fatty acids, vitamins & minerals in flaxseeds, the seeds need to be powdered, crushed, cracked, chopped-up, sliced-up or ground-up using a coffee grinder, adjustable pepper grinder or most simply, a blender with a sharp blade.

The resulting powder can be mixed with liquids or sprinkled on foods, though extra fluid must be drunk, as the soluble fibre/fiber absorbs a lot of water.

Although whole flaxseed keeps fresh at room temperature, once powdered, it's advisable to keep the powder in a cool dark place to minimise oxidation of any exposed fat. Flaxseed oil must be kept refrigerated with the lid on the bottle at all times after opening and it must never be used for cooking.

The oil is O.K. drizzled over hot food, as long as the food is eaten shortly afterwards. Oxidised flaxseed oil tastes bitter and has lost its health benefits, so it should either be chucked, used to varnish something or soften hardened putty. Unoxidised flaxseed oil has a nutty flavour, or it may taste a bit like tea. Powdered flaxseed has virtually no flavour.

See Milled flaxseed stability information.


How much flaxseeds and flaxseed oil do I need to eat each day?

Men are much poorer converters of alpha-linolenic acid (the omega-3 fatty acid in flaxseed) into DHA than women.

See Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men,

Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women and

Extremely Limited Synthesis of Long Chain Polyunsaturates in Adults: Implications for Their Dietary Essentiality and Use as Supplements.

Therefore, men should eat ~50g/day of ground flaxseed and women should eat ~25g/day. The amount of flaxseed oil for men is ~20g/day and the amount for women is ~10g/day. Vegan men should also supplement with ~1000mg/day of vegan DHA.


Where can I buy flaxseeds and flaxseed oil?

Flaxseed/linseed come in different colours. The cheapest linseed are brown/bronze ones which are often sold as bird seed in pet shops, but they can also be found in small independent health food shops. There are also golden linseed, which is the type most often found in supermarkets. Linusit and Granovita are two well-known brands. Granovita organic flaxseed oil is a good brand and it comes in dark bottles to keep light out, as light causes photo-oxidation of omega-3 fats.

Vegetarians & vegans, listen up!

By vegetarian, I mean someone who does not eat the flesh of animals. This includes fish and chicken. By vegan, I mean someone who does not eat any animal produce, including milk or eggs.

Dr. Michael Greger M.D. ("The Vegan M.D.") has a very informative and witty lecture Optimum Vegetarian Nutrition: Surprising New Research on Omega 3's and B12.

In a nutshell, vegetarians & vegans don't live any longer than omnivores – as shown in a study of 28,000 subjects. Vegetarians & vegans have the same rates of coronary heart disease as omnivores, but double the rates of degenerative brain diseases like Alzheimer's Disease. WHY? There are two reasons.

1) Vegetarians and vegans don't eat oily fish and most don't eat cracked or ground-up flaxseed/linseed either. This means a deficiency in omega-3 fats. This increases the risk of diabetes, certain cancers and coronary heart disease.

Men are much poorer converters of alpha-linolenic acid (the omega-3 fatty acid in flaxseeds) into DHA than women.

See Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men,

Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women and

Extremely Limited Synthesis of Long Chain Polyunsaturates in Adults: Implications for Their Dietary Essentiality and Use as Supplements.

2) Only animal produce naturally contains Vitamin B12. Lack of B12 in the diet raises the level of homocysteine in the blood, which damages artery walls. This raises the risk of coronary heart disease & doubles the risk of degenerative brain diseases like Alzheimer's Disease.

What to do?

1) Men should eat ~50g/day of ground flaxseeds and women should eat ~25g/day. The amount of flaxseed oil for men is ~20g/day and the amount for women is ~10g/day. Vegan men should also supplement with ~1000mg/day vegan DHA.

2) Eat foods fortified with vegan B12 or supplement with vegan B12.

'Nuff said?

See also Linseeds/Flaxseeds & Flaxseed oil and How I Un-Ruined My Teeth.

I was just thinking......

On a messageboard in a galaxy far far away, someone suggested that as many as one in three people in the UK could have impaired carbohydrate metabolism. This set me thinking.

London is 51degrees North of the Equator, so the sun has to pass through ~45% more atmosphere to reach us, compared to the Equator.

According to Elina Hyppönen & Chris Power, (edited) "The prevalence of hypovitaminosis D was highest during the winter and spring, when 25(OH)D concentrations less than 75nmol/L were found in 87.1% of participants, respectively; the proportion was 60.9%, respectively, during the summer and autumn."

Note that 75nmol/L was insufficient to give me normal Insulin Sensitivity. See Chiu, Chu, Go & Saad. However, greater than 160nmol/L was sufficient, but that was only obtained after I supplemented with 5,000iu/day of Vitamin D3 (25 x RDA).

A deficiency of omega-3 EFAs can cause Insulin Resistance (poor Insulin Sensitivity). See Ghafoorunissa, Ahamed Ibrahim, Laxmi Rajkumar & Vani Acharya, Storlien LH, Kraegen EW, Chisholm DJ, Ford GL, Bruce DG & Pascoe WS and Yam D, Bott-Kanner G, Friedman J, Genin I, Klainman E & Shinitzky M.The typical omega-6:omega-3 ratio in the British diet is ~15:1. This is partly due to the fact that animal produce from grain-fed animals contains a lot more omega-6 and a lot less omega-3 than it used to. See Is food less nutritious than it used to be? Andre Purvis investigates. In addition, people eat grains, nuts, seeds, oils & spreads high in omega-6 and don't eat much oily fish, powdered Flax-seeds (a.k.a. Linseeds) or Purslane (a plant that's relatively high in omega-3).

With all of these problems, I wonder what percentage of the UK population actually do have some degree of impaired carbohydrate metabolism? It might be more than one in three.

According to The eatwell plate, one third of our total Calories are supposed to come from bread, rice, potatoes, pasta and other starchy foods. All of these foods raise blood glucose. Impaired carbohydrate metabolism makes for roller-coaster blood glucose levels which encourages over-eating, leading to obesity (see my Blog post on Blood Glucose, Insulin & Diabetes.)

I think that that's enough thinking for now.

How to lose body-fat healthily.

Previous blog posts have been about Carbohydrates, Fats & Proteins. However, when you go shopping, you buy food. So this blog post is going to be about food. Updated!

1) If you're eating a high-carb diet, eat 6 small meals or 3 meals and 3 snacks per day to keep your blood glucose relatively stable. I used to believe that it also kept your metabolic rate high, but I now know this to be a myth. If you're the type of person who gets lowish blood glucose in the mornings (which may make you ravenously hungry and therefore highly likely to buy junk food when you're away from home), skipping breakfast is not advisable. If you're the type of person who isn't satisfied by small meals/snacks, a small number of large meals (Intermittent Fasting) is a better option.

2) Meals and snacks should contain proteins, fats and fibrous carbs.

3) Slow sugary/starchy carbs can be eaten in meals/snacks at breakfast and before/after workouts/exercise/intense activity. If/when you are sedentary, keep slow sugary/starchy carbs to a minimum. Keep fast sugary/starchy carbs to a minimum (except for the occasional treat or post-workout) as they can cause large fluctuations in blood glucose and insulin levels. The more intense exercise you do, the more slow sugary/starchy carbs you can eat.

4) Drink >1.5 litres of no-added-sugar watery drinks per day. If your urine is darker than straw, drink more. If you're weeing too often, drink less.

5) Balance your omega-6 and omega-3 essential fatty acids (EFAs) by eating about 100g of omega-3 rich oily fish (sild, sardines, pilchards, mackerel, herring, salmon, trout, fresh tuna etc) per day or supplement with fish oil capsules such that you get at least 2g of EPA+DHA per day. Please note that tinned tuna contains virtually zero omega-3 fat.
If you're vegetarian or vegan, eat 25g (women) or 50g ( men) of powdered linseeds (a.k.a. flaxseeds) per day with lots of fluids or supplement with flaxseed oil in bottles/capsules such that you get at least 10g (women) or 20g (men) of flaxseed oil per day.

6) Eat 2 to 3 portions of low-sugar fruits per day - preferably before meals/snacks. Minimise your consumption of high-sugar fruits.

Proteins are:- Meats, poultry, fish, eggs, cheese, Quorn, seeds, nuts, legumes (peas, beans & lentils).

Fibrous carbs are:- All vegetables that grow above ground level, bulbs (onions, leeks, garlic etc) and "vegetable" fruits (tomatoes, peppers, cucumbers/courgettes, aubergines, avocados, olives etc).

Slow sugary/starchy carbs are:- All-bran, no-added-sugar muesli, oats, sweet potatoes, lightly-boiled new potatoes eaten hot, cold or refrigerated, Basmati rice, non-overcooked legumes & root veggies, lumpy wholegrain rye breads, Burgen/Vogel's soya & linseed breads.

Fast sugary/starchy carbs are:- White wheat breads, wholemeal wheat breads, most breakfast cereals including Shredded Wheat, Weetabix, Cheerios, Grapenuts etc, sugar, sweets, chocolate, cakes, biscuits, cereal bars, sweetcorn, overcooked tubers e.g. jacket potatoes, overcooked root veggies, overcooked legumes e.g. baked beans.

High sugar fruits are:- Ripe & over-ripe bananas, grapes, pineapples, sweet apples, sweet pears, sultanas, raisins, currants and any dried fruits with added sugar.

Low sugar fruits are:- Berries, stone fruits, citrus, Granny Smith apples, Conference pears. Dried apple rings, apricots, pear halves, peach halves and prunes without added sugar are high in sugar but they release that sugar very slowly.

Fats are sats, monos and the EFAs mentioned above. Butter is high in sats and monos. Olive oil & spreads are high in monos. Sunflower/safflower/corn oils & spreads are very high in omega-6 EFAs - minimise your consumption of these. Don't fry or roast with high-EFA oils as they oxidise and convert into trans-fats too quickly. Meats contain sats, monos and some EFAs. Minimise your consumption of anything with the word "hydrogenated" in the ingredients list.

Some foods fall in-between categories like yellow bananas which are medium speed sugary/starchy carbs. Green bananas are slow carbs and black bananas are fast carbs.

Depending on your insulin sensitivity, speed of metabolism and exercise levels, you may get away with eating fast sugary/starchy carbs - you'll just have to "suck it and see".

One final bijou tip-ette:- Avoid walking down "dodgy" supermarket aisles (confectionery, cereals, booze, fizzy drinks) as "What the eye don't see, the heart don't grieve over".

Happy New Year folks!

Cont'd on How to lose body-fat healthily, Part 2.

A blast from the past.

Look who's turned up on the BBC food boards after a 4-5 years absence. A big "Welcome back" to Zoë Harcombe, who has the site 'Why do you overeat? When all you want is to be slim' and The Harcombe Diet.

We agree on most things. The problem with counting Calories is that, if you reach your Calorie limit by 6pm, what do you do? Spend the rest of the evening hungry and go to bed with a rumbling tummy & hunger pangs? Or just have one teensy-weensy bite to eat, which turns into a "nom-a-thon"? I know what I would do, as I can resist anything.......except temptation!

What we don't agree on is that Calories don't count. I say that they do. So does Lyle McDonald and Anthony Colpo. For people who are restrained to a hospital bed, changing the relative proportions of carbohydrate & fat (keeping protein constant) in their diet makes no difference whatsoever to their long-term weight gain/loss (ignoring glycogen + water weight differences). What it does make a difference to is how much these restrained people would beg for food. On a high-carb diet, I was much hungrier than when I was on a low-carb diet. This is why I ate way too much on the former diet (& got fat) and ate much less on the latter diet (& got slim).

It's thought that Insulin is the only hormone responsible for body-fat storage. This isn't correct.

Insulin makes the body store glucose (from dietary carbohydrates) and amino acids (from dietary proteins) and stops the body from burning fats. Therefore, having chronically-high serum insulin levels (hyperinsulinaemia) is not desirable for people wishing to burn body-fat for fuel.

As we all know, dietary carbohydrate raises serum insulin levels by raising blood glucose. See http://www.mendosa.com/gilists.htm.

However, dietary protein also raises serum insulin levels. See http://www.mendosa.com/insulin_index.htm.

Eating most fats with carbohydrates raises serum insulin levels even higher still, although fats lower the glucose response. See http://jn.nutrition.org/cgi/reprint/133/8/2577.pdf. What do junk foods mostly consist of? High-GI carbohydrates + fats. However, omega-3 fats reduce the hyperinsulinaemia caused by the other fats. See http://diabetes.diabetesjournals.org/cgi/reprint/53/suppl_1/S166.pdf.

Eating fat on its own does not raise serum insulin levels. See http://ajcn.nutrition.org/content/75/3/505.full.pdf. However, it's still possible to gain body-fat by eating too many Calories of dietary fat. Acylation Stimulating Protein (ASP) makes the body store dietary fat as body-fat. See http://www.jlr.org/cgi/reprint/30/11/1727.pdf.

The amount of food that free-living people (i.e. people who are not restrained to a hospital bed) eat depends mostly on their appetites. This is affected by the food that they eat (the low blood glucose that follows hyperinsulinaemia causes severe hunger pangs) and also advertisements. Watch this video of Adam Curtis' BBC documentary The Century Of The Self - Part 1 of 4.

I hope that you all had a good Christmas.